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In 1989, a group of Canadian researchers discovered that grapefruit juice increased the potency of a blood
pressure drug they were testing. The pairing came about after they tried to use the juice to mask the taste of the
alcohol; the trial was held to uncover potential side effects when the alcohol was combined with the drug. The
scientists were startled, but had difficulty proving why the grapefruit juice had such an effect. According to the
New York Times, studies done on grapefruit juice have
concluded that it sometimes interferes with an enzyme, CYP 3A4, which can reduce the potency of many drugs or help them
pass out of the body faster. This means that the body might receive more of an impact from a given drug if it is taken
with grapefruit juice.
Grapefruit juice does not always produce this effect, however. It interacts with CYP 3A4 in the intestines, so it does not effect injected drugs, only those taken orally. It also is very unpredictable. Different people have different amounts of CYP 3A4 in their intestines and different glasses of grapefruit juice will react differently. It is most likely to produce potentially harmful effects with cholesterol-lowering drugs and SSRIs, like Prozac, which is used to treat depression. The best thing to do is to avoid grapefruit juice if your doctor recommends it.
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3-22-2006 @9:10AM Charlie said... I wonder why this is so surprising. It was once known that taking vitamin C with LSD increased the intensity as it does with "magic" mushrooms and sometimes marijuana. But yeah, it's probably the intestine thing.
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3-22-2006 @9:12AM Charlie said... Why should this be so surprsing. It was once know that taking Vitamin C with LSD would increas the intesity of the drug. The same may be said for "magic" mushrooms and sometimes even mariujuana. Maybe not. Who knows.
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3-22-2006 @11:08AM Robyn said... I was sorta thinking along the same lines from the days when I used to do E, but is it the vitamin C? I mean, do all these druggies know something the scientists don't?
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